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According to popular theory:

Sets of one to five repetitions primarily develop strength, with less impact on muscle size and none on endurance.
Sets of six to twelve repetitions develop a balance of strength, muscle size and endurance.
Sets of thirteen to twenty repetitions develop endurance, with some increases to muscle size and limited impact on strength.
Sets of more than twenty repetitions are considered to be focused on aerobic exercise. They do still use the anaerobic system, but usually at a rate through which it can consistently remove the lactic acid generated from it.
Individuals typically perform one to six sets per exercise, and one to three exercises per muscle group, with short breaks between each set - the specific combinations of reps, exercises, sets and break duration depends on the goals of the individual program. The duration of these breaks determines which energy system the body utilizes. Performing a series of exercises with little or no rest between them, referred to as "circuit training", will draw energy mostly from the aerobic energy system. Brief bursts of exercise, separated by breaks, are fueled by anaerobic systems, which use either phosphagens or glycolysis.

It has been shown that for beginners multiple-set training offers minimal benefits over single set training with respect to either strength gain or muscle mass increase, but for the experienced athlete multiple-set systems are required for optimal progress. Beginning weight-trainers are in the process of training the neurological aspects of strength, the ability of the brain to generate a rate of neuronal action potentials that will produce a muscular contraction that is close to the maximum of the muscle's potential.

Training to achieve different performance goals (from "Supertraining" by Dr. M. C. Siff)

Variable Strength Power Hypertrophy Endurance
Load (% of 1RM) 80-100 70-100 60-80 40-60
Reps per set 1-5 1-5 8-15 25-60
Sets per exercise 4-7 3-5 4-8 2-4
Rest between sets (mins) 2-6 2-6 2-5 1-2
Duration (seconds per set) 5-10 4-8 20-60 80-150
Speed per rep (% of max) 60-100 90-100 60-90 60-80
Training sessions per week 3-6 3-6 5-7 8-14

Weights for each exercise should be chosen so that the desired number of repetitions can just be achieved. Proper form ensures that the targeted muscles are trained and also serves to prevent injury.

 

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